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Levonorgestrel and other drugs to reduce the risk of bleeding. Use in pregnancy has not been shown to lead an increased risk of birth defects or premature rupture of membranes. Side Effects The following symptoms and signs may occur during the first few months of contraceptive use: Mood changes Depersonalization Increased appetite Abdominal cramps and other pain, particularly in first 2 weeks Unexplained, heavy bleeding and vaginal spotting that does not stop, and may involve both ovulatory nonovulatory months Changes in sleep patterns Proteinuria, increased urinary protein (polyuria), and loss during exercise or other strenuous activity Preeclampsia, which may be due to antepartum bleeding Bleeding between menstrual periods (estrogen-sensitive bleeding) Weight gain Fever The most common side effects of contraceptive pills that occur during the first 1/3 to 1 year of use include: Mood changes such as irritability, depression, nervousness, insomnia, decreased libido, and loss of appetite Anxiety Nausea Numbness and tingling Vaginitis Vaginaseal pain Pain during sexual intercourse Breast tenderness Vaginal bleeding and spotting, which is usually menstrual in appearance (menses and bleeding) does not end with a period Changes in libido or sexual performance Loss of weight Frequent menstrual periods A study carried out in Finland, published The Journal of Clinical Endocrinology and Metabolism (2003), reported that women taking the contraceptive pill, particularly when used with progestin, may be at risk of developing ovarian cancer at younger ages than those not taking hormonal contraception. The risk was found to be increased after 1 year and remained more common during the second and third decade of use. A meta-analysis on 15 clinical studies, performed by the International Agency for Research on Cancer (IARC), indicated that, in women ages 20 to 39 (age range 19 42), increased risk of invasive breast cancer may be increased more than 4-fold if estrogen-only combined with a progestin was used, compared with other oral contraceptive methods. Risk did not vary by age at diagnosis. The risk of invasive ovarian cancer increased by an estimated 17% to 20%. A meta-analysis performed in Germany examined the risk of breast cancer, and found that hormone replacement therapy, including oral contraceptives was associated with increased risk of breast cancer among women aged 30 to 39. The most recent meta-analysis on topic published in The Lancet on December 14, 2012, found that oral contraceptives and other hormonal were strongly associated with a significantly reduced risk for several types Amitriptyline hydrochloride australia of cancer when compared with no contraceptives. Risk reductions were observed in breast, endometrial, cervical, ovarian, hepatocellular, renal cell, pancreatic, renal, and stomach cancer. The study also found that estrogen use in combination with progestin was associated increased risk of endometrial, ovarian, and other cancer when compared with no use of hormonal products. Risk increases were also associated with combined estrogen progesterone, progestin estrogen, and combined estrogen with progesterone. The current study provides important data that provide evidence of a link between oral contraceptive use, contraception use with progestin, and ovarian cancer risk, which, when combined with other data on oral contraceptives and ovarian cancer, provides the strongest possible evidence for association. The main strengths of this study include its large sample size and statistical power, extensive ascertainment of both oral contraceptive and hormonal use cancer outcomes, detailed consideration of numerous factors (such as age at initiation of use and long history oral contraceptive use) influencing ovarian risk. In conclusion, the current findings support that US use of hormones and/or progestins, particularly ethinyl estradiol combined with other Reactine online coupon progestins, or progestin-only Clomiphene dosage for hypogonadism products for contraception, increases the risk of various diseases.



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